![]() 7 Data were compiled by using MATLAB (V9.55, Mathworks, Natick, Massachusetts), and statistical analyses were completed in Excel (V12.0 071130, Microsoft, Redmond, Washington). ![]() We decided a priori, that a ≥10% difference between the actual body weight and the IBW would be clinically important. 14 The Kruskal-Wallis test was used to detect significant differences among the methods of IBW calculations by using the actual body weight as a reference. 13 Because the data were not normally distributed, the Wilcoxon signed-rank test was used to compare the IBW with the actual body weight. Bland-Altman analysis was used to assess the individual agreement of each IBW method and the actual body weight. The mean differences between each IBW method and the actual body weight for all the subjects were then calculated and their respective percent error from the actual body weight was reported as median (interquartile range). 8 Further, we aimed to assess the proportion of pediatric subjects who had a clinically important difference between the IBW and actual body weight. 7 Therefore, we sought to compare the actual body weight with 3 commonly used methods for determining IBW in pediatric subjects: the McLaren-Read (a growth chart method), Moore (a growth chart method), and body mass index (BMI) (indexed equation based on height, sex, and age) methods. Few studies have assessed the performance and need for IBW methods in a pediatric population. 7Ī universal method for determining the IBW in children on mechanical ventilation is elusive. However, calculation of the IBW for the titration of mechanical ventilation settings is not uniformly used. 6 Titration of V T relative to the IBW in the pediatric ICU is especially important because the size, height, and body composition of the population vary tremendously. 4, 5 Importantly, the calculation of the IBW and its use during mechanical ventilation is recommended in the pediatric ICU. Lung-protective ventilation may also be beneficial pediatric and adult in patients who do not have ARDS but receive mechanical ventilation in the ICU or operating room. The physiologic rationale for titrating V T to the ideal body weight (IBW) is that normal lung volumes are a function of age, sex, and thorax anatomy. 3 It is broadly understood that several factors affect normal V T, including age, sex, height, and thorax dimensions. 1, 2 Key components of lung-protective ventilation include the application of low tidal volumes (V T), elevated PEEP, and permissive hypercapnia. ![]() Lung-protective ventilation strategies have been shown to reduce mortality during adult ARDS.
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